Molecular Dynamics software
  • AMBER (Assisted Model Building with Energy Refinement)
  • CHARMM (Harvard College) 
  • Discover (Molecular Simulations Inc)
  • GROMOS (ETH Zürich)
  • MacroModel (Schrödinger, Inc) graphical construction of complex chemical structures and the application of molecular mechanics and dynamics techniques in vacuo or in solution. 
  • VMD (Theoretical Biophysics Group, University of Illinois)
Crystallography and NMR software
  • CNS (A. Brünger et al, Yale University) - Crystallography & NMR System
  • CCP4 (macromolecular crystallography program suite)
  • DYANA is a new program for NMR structure calculation that provides all functionality of its predecessor, DIANA, and many new features - Peter Güntert
  • DINOSAUR - "A set of programs for structure refinement using direct NOE restraints" - Alexandre Bonvin, while with the NMR Group at Utrecht University, the Netherlands. 
  • IRMA2 "The IRMA procedure calculates distances from experimental NOE spectra with the use of the full relaxation matrix approach". the NMR Group at Utrecht University, the Netherlands.
  • "O" (protein crystallographic package)
  • PROTEIN (Wolfgang Steigemann) program system for the crystal structure analysis of macromolecules
  • TALOS - TALOS is a database system for empirical prediction of phi and psi backbone torsion angles using a combination of five kinds (HA, CA, CB, CO, N) of chemical shift assignments for a given protein sequence. (courtesy of the Ad Bax Group). 
  • X-PLOR (A. Brünger, Yale University) 
Quantum mechanical calculations
Molecular graphics and visualisation
  • BRAGI ( interactive protein-modelling program)

  • Cn3D (allows to view 3-dimensional structures from NCBI's Entrez database)
  • GRASP Graphical Representation and Analysis of Structural Properties (Columbia University) 
  • InsightII (Molecular Simulations Inc) 
  • MidasPlus Molecular Display and Simulation System
  • MOLDEN (package for displaying Molecular Density from the Ab Initio packages GAMESS and GAUSSIAN and the Semi-Empirical packages Mopac/Ampac)
  • Molecular Surface Viewer - MSV (M. Sanner, Scripps Research Institute) 
  • MOLMOL (ETH Zürich) 
  • MOLPRO (Universität Stuttgart) 
  • MOLPRO (University of Birmingham)
  • MolScript (P. Kraulis, Uppsala) 
  • ORTEP (Oak Ridge National Laboratory) - Crystal Structure Illustrations
  • PovChem(Paul Thiessen) molecular graphics software
  • PREPI (Protein REPresentations Interactively)
  • RasMol (Roger Sayle) 
  • Raster3D (Biomolecular Structure Center at the University of Washington) 
  • RIBBONS (Mike Carson) 
  • SPARTAN (Wavefunction, Inc.) - molecular modelling and visualisation program suite
  • SPOCK (Jon A. Christopher and Texas A&M University) molecular graphics program
  • SYBYL (Tripos Ass.) 
  • WHATIF (G. Vriend, Heidelberg) - 3D modelling services
  • Receptor-ligand interactions
  • DOCK (docking of flexible ligands into protein target)
  • FlexX (automatic prediction of receptor-ligand interactions) 
  • FlexS (automatic structural alignment of small organic molecules) 
Protein and DNA structure and sequence analysis
  • CURVES (Laboratoire de Biochimie Theorique, Paris) - helical analysis of irregular nucleic acids 
  • DELILA Programs (T. Schneider, NCI/FCRDC, Frederick, MD) - Software for Information Analysis of Protein and Nucleic-acid Sequences
  • DSSP - protein secondary structure assignment program
  • Dotter  A dot-matrix program with interactive greyscale rendering for genomic DNA and Protein sequence analysis 
  • Modeller (Program for homology protein structure modelling by satisfaction of spatial restraints) 
  • PROCHECK
  • PROCHECK_NMR
  • SQUID (T. J. Oldfield, Department of Chemistry, University of York)
Protein properties calculations
NMR processing and analysis pachages
  • CORMA " (COmplete Relaxation Matrix Analysis) is a FORTRAN program for calculating the dipole-dipole relaxation matrix for a system of protons and converting that to intensities expected for a 2DNOE experiment." - UCSF, USA.
  • CROSREL - "a program for the analysis of ROESY and NOESY NMR data" - Bas R. Leeflang, Utrecht, The Netherlands. 
  • DASHA Model-Free Analysis of Protein Dynamics from Heteronuclear NMR Relaxation Data, and DIFFC: Hydrodynamic calculations for proteins with known spatial structure - both developed at the Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, RAS, Moscow, Russia; General advising - Prof. Alexander S. Arseniev.
  • DSYMPC "NMR SIMULATION AND ITERATION TOOLS FOR PCs" - G. Hdgele at al., Duesseldorf, Germany.
  • FELIX - NMR data processing, analysis and assignment program (Molecular Simulations).
  • FIRM - Full Iterative Relaxation Matrix program. "Interactive program (fortran) for calculating NOEs of a structural model using the relaxation matrix approach. Distances, corrected for the effects of spin diffusion, can be back-calculated from experimetal NOEs using a hybrid relaxation matrix. Includes features for simulating internal motions". (S. Edmondson, Southern Illinois University). 
  • GAMMA - "a library written for simulation of Nuclear Magnetic Resonance experiments" - ref: S.A. Smith, T.O. Levante, B.H. Meier and R.R. Ernst (ETH, Switzerland); Computer Simulations in Magnetic Resonance: An Object-Oriented Programming Approach, Journal of Magnetic Resonance, November 1993, Series A. (ftp link to ETH).
  • Gifa "The Gifa program is a multi-purpose NMR program. It is designed for the processing, the display and the analysis of 1D, 2D & 3D NMR data-sets." M.A.Delsuc, CBS, France.
  • MARDIGRAS "(Matrix Analysis of Relaxation for DIscerning the Geometry of an Aqueous Structure) is a FORTRAN program for calculating proton-proton distances from cross-peak intensities measured from a 2D NOE experiment."- UCSF, USA.
  • MestRe-C - from Spain - MestRe-C 2.0 is a program designed to process and plot 1D NMR spectra on PC’s running Windows 95/98/NT 4.0. It imports files from most spectrometers and includes a number of useful tools (courtesy F. Javier Sardina, Universidad de Santiago de Compostela, SPAIN). 
  • MEX and CIFIT - Alex Bain: "For simulation of exchanged-broadened lineshapes for uncoupled spin systems (MEX) and "to analyse selective inversion experiments (Hoffman-Forsen) for slow chemical exchange (CIFIT). 
  • MORASS - Multiple Overhauser Relaxation AnalysiS and Simulation. "MORASS uses a full hybrid matrix eigenvalue/eigenvector solution to the Bloch equations to derive cross-relaxation rates and interproton distances. MORASS analyzes 2D NMR NOESY data from oligonucleotides and proteins to evaluate cross-relaxation rates from which interproton distances are obtained" - R.P. Meadows, C.B. Post, and D.G. Gorenstein, Purdue Univ. USA. 
  • NMRPipe - NMRPipe provides comprehensive facilities for Fourier processing of spectra in one to four dimensions, as well as a variety of facilities for spectral display and analysis. It is currently used in over 300 academic and commercial laboratories (courtesy of the Ad Bax group). 
  • NUMARIT - "A spin simulation/iteration package for the X32", by Kirk Marat. 
  • PERCH - (PEak reseaRCH) - an integrated NMR-software package for research, analytics and education. The spectral analysis and simulation up to 10 spins is based on the program MLDC (Modified LAOCOON with Dipolar Couplings)" - PERCH Project, Univ. of Kuopio, FINLAND.  source
  • PC Software: APT, DECAY, DEPT, FIDUNK, FTNMR Simulator, HETJ-2D, HOMOJ-2D, IRREADER, NMRSM, UNKINP, XHCORR from Dr. Harold M. Bell, Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA
  • PRONTO Pronto: The PROtein Nmr TOol - Mogens Kjaer, Carlsberg Laboratory, Denmark. Source.
  • RMN - a Nuclear Magnetic Resonance (NMR) data processing program for the Macintosh. 
  • SIMPSON - (SIMulation Package for SOlid-state Nmr spectroscopy) - A solid-state NMR simulation program with emphasis on ease of use. Multiple pulses, spins, and dimensions. Input files written in Tcl demonstrate simulations of 20 major solid-state experiments. Authors: Mads Bak and Jimmy T. Rasmussen
  • Sparky - Graphical NMR assignment program for proteins and nucleic acids. Runs under Windows, Linux, or Unix. 
  • SwaN-MR : "An NMR processing software for the Macintosh. It reads 1D, 2D, 3D and 4D spectra coming from many spectrometers and its feature list is comparable to those of commercial packages". Giuseppe Balacco. Source 
  • V - an interactive software system for MR signal processing. Source 
General use scientific software
  • gnuplot - An Interactive Plotting Program
  • NLREG - Nonlinear Regression Analysis Program
Image Visualisation software